Scientific Program
İstanbul MS Days
İstanbul MS Days
| 16:00-17:00 | Panel I Rational use and cost effectiveness of diagnostic tools in MS and related disorders in Turkiye (In Turkish) Chairs: Kadriye Ağan Panelists: Serpil Bulut, Levent Sinan Bir, Serpil Demirci, Haluk Gümüş, Mesrure Köseoğlu, Bilgin Öztürk |
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| 17:00-17:45 | Satellite Symposium – Sanovel Experience of Teriflunomide with Cases Chairs: Ayşe Nur Yüceyar, Murat Terzi |
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| 1. Treatment Experiences and Decision-making 2. The Importance of Current Biomarkers in Treatment Strategies Speakers: Nilüfer Kale İçen, Mehmet Fatih Yetkin |
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| 17:45-18:00 | Break  |
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| 18:00-19:30 | Panel II Treatment options and barriers in treating the individual with MS in Turkiye (In Turkish) Chairs: Ömer Faruk Turan, Sabahattin Saip Panelists: Sıla Usar İncirli, Ufuk Aluçlu, Münife Neyal, Cavit Boz, Sema Saltık, Esra Gürsoy |
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| 19:30-19:45 | Rational Drug Use Session Chair: Saltanat Mert Speaker: Tahir Yoldaş |
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Dinner  |
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| 08:00 - 09:00 | Oral Poster Presentations | ||
| Poster Station I Dürdane Aksoy, Yaşar Altun |
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| Poster Station II Ferah Kızılay, Gürdal Orhan |
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| Poster Station III Nuray Bilge, Abdülkadir Tunç |
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| Poster Station IV Emine Rabia Koç, Ahmet Kasım Kılıç |
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| Poster Station V İrem Tiftikçioğlu, Yusuf Tamam |
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| 09:00 – 09:45 | Morning Satellite - Abdi İbrahim SIGNIFICANT ADVANCEMENTS IN MS TREATMENT: Fampiridine in Symptomatic Management Chair: Murat Terzi |
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| The Fampiridine Molecule in Multiple Sclerosis: Key Clinical Studies
Application of Fampiridine in Clinical Practice Fampiridine Therapy: Case Study Insights Speaker: Melih Tütüncü |
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| 10:00 - 10:45 | Effective Presentation Skills for Scientists Janet Hafler Chairs: Nilüfer Kale İçen, Nefati Kıylıoğlu |
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| 11:00 – 12:00 | TURKISH MS PANEL - In Turkish Building future-proof careers for young MS specialists in Türkiye Chairs: Murat Terzi, Mehmet Fatih Yetkin Speakers: Serkan Demir, Atay Vural, Tuncay Gündüz, Sedat Şen |
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| 12:00-12:45 | Lunch & Satellite Symposium - Merck Mavenclad Usage in MS Treatment Chair: Cavit Boz |
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| Mavenclad in MS Treatment Serhan Sevim |
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| Mavenclad Usage in Elderly Patients Bruce Hughes |
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| 13:00 – 14:00 | OFFICIAL OPENING | ||
| 13:00 – 13:10 | Welcome address 1: History of Istanbul MS Days Aksel Siva |
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| 13:10 – 13:20 | Welcome address 2: From local roots to global aspirations – Dark Side of the Moon? Orhun H. Kantarci |
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| 13:20 – 17:20 | SESSION-1 / I: From Posers’ Criteria to refined disease definitions of 2024 in inflammatory demyelinating diseases Discussants & Chairs: Jack Antel & Husnu Efendi & Axel Petzold |
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| 13:20 – 13:40 | The clinician-scientist – finding the right questions for the right answers Brian G. Weinshenker |
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| 13:40 – 14:00 | The scientist-clinician – using epidemiology evidence to develop individualized clinical practice Ellen Mowry |
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| 14:00 – 14:20 | The clinician-clinician – Value of experience-based medicine in the extremes of disease Thomas Berger |
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| 14:20 – 14:40 | The scientist-scientist – Developing models that reflect clinical questions accurately Katerina Akassoglou |
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| 14:40 – 15:00 | Discussion | ||
| 15:00 – 15:20 | Break |
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| 15:20 – 17:00 | SESSION-1 / II: Updates in Diagnostic Criteria and phenotyping definitions of inflammatory demyelinating diseases in 2024 and beyond Discussants & Chairs: Jack Antel & Husnu Efendi & Axel Petzold |
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| 15:20 – 15:40 | The 2024 MS Diagnostic Criteria – What does it change? Xavier Montalban |
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| 15:40 – 16:00 | Upcoming IPND-2025 Criteria – Will it add anything? Kazuo Fujihara |
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| 16:00 – 16:20 | Real world use examples of CVS & PRLs Jiwon Oh |
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| 16:20 – 17:00 | Do we need more detailed or more practical diagnostic criteria? Chairs |
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| 17:00 – 17:30 | Q&A, Discussion | ||
| 17:30 – 17:50 | Break |
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| 17:50 – 20:00 | SESSION-2: Can we use science to fine tune health care delivery to the underserved? Discussants & Chairs: Aslı Tuncer & Mohamadali Sahraian & Magd Zakaria |
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| 17:50 – 18:10 | The real-world needs of the underserved countries Riad Goudhier |
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| 18:10 – 18:30 | Pitfalls in quantifying needs of the underserved and how to improve it Rana Karabudak |
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| 18:30 – 18:50 | Socialized vs. free-market economy for delivering healthcare to people in need Andrew Chan |
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| 18:50 – 19:20 | Objective definitions of race & ethnicity – beyond the conventional Philip L. De Jager |
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| 19:20 – 19:50 | Q&A, Discussion | ||
| 20:00 | Dinner |
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| 08:00 - 09:00 | Oral Abstract Presentations | ||
| HALL A Ayşe Sağduyu Kocaman, Aylin Akçalı |
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| HALL B Özlem Ethemoğlu, Aslı Köşkderelioğlu |
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| HALL C Erdem Toğrol, Belgin Petek Balcı |
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| HALL D Semra Öztürk Mungan, Caner Feyzi Demir |
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| HALL E Yılmaz İnanç, Mehmet Tecellioğlu |
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| 09:00 – 09:15 | Break |
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| 09:15 – 09:35 | Adjusting for geography in epidemiology studies in MS Alberto Ascherio |
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| 09:35 - 09:40 | Q&A, Discussion | ||
| 09:40 – 12:00 | SESSION-3: Translating existing biomarkers to clinic? Discussants & Chairs: Naila Makhani &Yesim Beckmann & Erdem Tüzün |
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| 09:40 - 10:00 | Low field portable MRI - effective deployment to clinic – Serhat Okar |
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| 10:00 -10:20 | Utility of cervical cord MRI in MS diagnosis and prognosis Cristina Azevedo |
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| 10:20 – 10:40 | Break |
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| 10:40 – 11:00 | CSF biomarkers in MS Hayrettin Tumani |
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| 11:00 – 11:20 | Integrating multiple biomarkers to diagnose, prognosticate and treat in the real world – The RIS experience Darin Okuda |
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| 11:20 – 12:00 | Q&A, Discussion | ||
| 12:00 – 12:45 | Lunch Satellite Symposium (Farmanova/ Novartis) Chair: Hüsnü Efendi |
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| A New Era of B Cell Therapies: Ofatumumab Speaker: Patrick Vermersch |
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| 13:00 – 15:20 | SESSION-4: Translating “futureomics” to clinic today? Chairs / Panelists: Eda Tahir Turanlı & Boris Zalc |
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| 13:00 – 13:20 | Role of genomics in early diagnosis of MS Anat Achiron |
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| 13:20 - 13:40 | Power of bioinformatics to solve complex proteomics of MS - Mika Gustafsson |
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| 13:40 – 14:00 | Immunomics to practice in MS Amit Bar-Or |
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| 14:00 – 14:20 | Break |
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| 14:20 – 14:40 | Radiomics to delineate complex phenotypes in MS Korhan Büyüktürkoğlu |
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| 14:40 - 15:00 | Pitfalls of integrating omics – human vs AI? Vilas Menon |
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| 15:00 – 15:20 | Q & A Discussion | ||
| 15:20 - 15:40 | Break |
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| 15:40 – 18:00 | SESSION-5: The MS continuum - polymorphic definition of relapses and progressive MS Discussants & Chairs: Nur Yuceyar & Refik Pul & Ugur Uygunoglu |
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| 15:40 – 16:00 | The pathologist’s view of MS phenotypes Bruce Trapp |
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| 16:00 – 16:20 | MRI markers of MS phenotypes Daniel Ontaneda |
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| 16:20 - 16:40 | Non-MRI imaging biomarkers of MS phenotypes Peter A. Calabresi |
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| 16:40 – 17:00 | Break |
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| 17:00 – 17:20 | Relapses & Pseudorelapses – do we need updated definitions Eoin P. Flanagan |
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| 17:20 - 17:40 | Towards practical composite metrics of preclinical and subclinical MS definitions Orhun Kantarcı |
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| 17:40 – 18:00 | Q&A, Discussion | ||
| 18:00 - 18:20 | Break |
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| 18:20 – 19:50 | SESSION-6: Using molecular imaging in MS – towards a practical goal Discussants & Chairs: Catherine Lubetzki & Murat Kürtüncü |
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| 18:20 - 18:40 | PET markers of myelin and oligodendrocytes Burcu Zeydan |
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| 18:40 – 19:00 | PET markers of microglia function Laura Airas |
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| 19:00 – 19:20 | PET Astrocyte imaging markers Bruno Stankoff |
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| 19:20 - 19:50 | Q&A, Discussion | ||
| 20:15 | Dinner |
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| 08:15 - 09:00 | Morning Satellite - Alexion Exploring AQP4+ NMOSD: Diagnosis, Pathophysiology and Eculizumab Treatment through Case Studies |
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| 08:15-08:35 | Opening, AQP4+ NMOSD Pathophysiology and Diagnosis of the Disease Ayşe Altıntaş |
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| 08:35-08:55 | Eculizumab Treatment in Patients Diagnosed with AQP4+ NMOSD, Case Examples Kazuo Fujihara |
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| 08:55-09:00 | Q&A | ||
| 09:00 – 09:15 | Break |
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| 09:15 – 12:00 | SESSION-7: The treatment of MS today and tomorrow Chairs / Panelists: Ayşe Altıntaş & Dimitrios Karussis |
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| 09:15 - 09:35 | Treating MS in the young age Silvia Tenembaum |
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| 09:35 – 09:55 | How to treat MS in the old age Nikolaos Grigoriadis |
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| 09:55 - 10:15 | Hormones and adjunct therapies in MS Kerstin Hellwig |
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| 10:15 - 10:30 | Break |
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| 10:30 – 10:50 | New developments in B cell depletion David Hafler |
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| 10:50 – 11:10 | Microglia targets – BTK inhibitors and beyond Daniel Reich |
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| 11:10– 11:30 | How to apply advanced imaging modalities for future clinical trials Nicola De Stefano |
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| 11:30 – 12:00 | Q&A, Discussion | ||
| 12:00 – 12:45 | Lunch & Satellite Symposium - Roche Chair: Uğur Uygunoğlu |
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| Timing of Ocrelizumab in MS: Clinical impact and efficacy of On Time Initiation Enric Monreal Laguillo |
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| 13:00 – 15:30 | SESSION-8: Rethinking trial design in multiple sclerosis Chairs / Panelists: Hans-Peter Hartung & Melih Tutuncu & Ugur Bilge |
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| 13:00 – 13:20 | Sex and ethnicity impact on clinical trial results Nabeela Nathoo |
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| 13:20 - 13:40 | Impact of limited recovery from relapses in practice and in clinical trials Claire Riley |
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| 13:40 – 14:00 | Designing future proof clinical trials with multiple variables a priori Maria Pia Sormani |
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| 14:00 – 14:20 | Break |
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| 14:20 – 14:40 | Missing spinal cord data and beyond in clinical trials – mismatch with clinical practice Matilde Inglese |
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| 14:40 - 15:00 | Using AI to model for prognostic variables in clinical trials Cristina Granziera |
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| 15:00 – 15:30 | Q & A, Discussion | ||
| 15:30 - 15:45 | Break |
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| 15:45 – 18:30 | SESSION-9: Treating the whole spectrum Discusssants & Chairs: Nasrin Asgari & Paulus Rommer & Najib Kissani |
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| 15:45 – 16:05 | Sensitivity and specificity of laboratory biomarkers in MS, NMO and MOG Orhan Aktas |
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| 16:05 – 16:25 | The challenges of treating overlapping autoimmune diseases with MS Aksel Siva |
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| 16:25 – 16:45 | The new NMO era of treating NMO – What should be the first line? Friedemann Paul |
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| 16:45 – 17:05 | Treating MOGAD – where are we now? Jacqueline Palace |
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| 17:05- 17:30 | Discussion | ||
| 17:30 – 17:45 | Break |
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| 17:45- 18:45 | SESSION-10: Innovations in MS Chairs: Gülşen Akman Demir & Serhan Sevim |
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| 17:45 – 18:05 | Where is the next innovation in treating inflammatory-demyelinating disease spectrum Heinz Wiendl |
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| 18:05 – 18:25 | mRNA vaccines for MS and autoimmune diseases Mustafa Diken |
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| 18:25 – 18:45 | Q&A, Discussion | ||
| 18:45 – 19.15 | Istanbul MS Days Lecture Chairs: Rana Karabudak & Husnu Efendi & Orhun Kantarcı & Aksel Siva |
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| Patient reported outcomes in MS - What will be the role of PROs in future MS care? Giancarlo Comi |
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| 19:15 – 20:15 | Summary and review of the meeting by the young Turkish MS Experts Chairs: Özgül Ekmekçi, Burcu Altunrende Panelists: Cihat Uzunköprü, Bilge Piri Çınar, Meral Seferoğlu, Mesude Tütüncü, Destan Bünül |
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| 20:30 | Faculty - Farewell Dinner |
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